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Beklo 10mg Tablet

Beklo 10mg Tablet
-14 %
Product price11৳
Special price10৳
Stock Status
In Stock
Product code
8199
Brand

Product model Model
Total Reviews
Official Products 100% Official Products
Authorized Showroom Brand Bazaar
Beklo 10mg Tablet
10৳
11৳
Ex Tax: 10৳

Beklo 10mg Tablet-

Price in Bangladesh

 

Beklo 10mg Tablet

Indications

Baclofen is indicated in-
  • Spasm.
  • Reflex muscle contractions.
  • Indirect effects of treatment with Baclofen include, improved sleep patterns, improvement in bladder and sphincter function and helps in the prevention and healing of decubitus ulcers.
  • Spasticity resulting from multiple sclerosis.
  • Spinal cord injuries and other spinal cord diseases.
  • Muscle spasm of cerebral origin especially infantile cerebral palsy.
  • Cerebrovascular accidents or neoplastic or degenerative brain disease.
  • Tension-type headache.

Therapeutic Class

Centrally acting Skeletal Muscle Relaxants

Description

Baclofen is a centrally acting skeletal muscle relaxant and an antispastic agent with a spinal site of action.

Pharmacology

Baclofen is an effective muscle relaxant and antispastic agent with a spinal site of action. Its mode of action is not fully understood. Baclofen inhibits both monosynaptic and polysynaptic reflexes at the spinal level by stimulating the GABAB-receptors, which inhibits the release of glutamate and aspartate. It may also act at intraspinal sites producing CNS depression. Neuromuscular transmission is not affected by Baclofen. Baclofen also exerts an antinoceptive effect but the clinical significance of this is unknown.

Dosage & Administration

Baclofen should be taken during meals with a little liquid. Baclofen should be given in divided doses preferably 3 times daily for adults and 4 times daily for children. The lowest dose compatible with an optimal response is recommended. If benefits are not evident after a 6 to 8 week trial period, patients should be slowly withdrawn from the drug. Adults: Start therapy at low dosage and increase gradually until optimum effect is achieved (usually between 30-80mg daily). The following dosage titration schedule is suggested:
  • 5 mg three times a day for 3 days
  • 10 mg three times a day for 3 days
  • 15 mg three times a day for 3 days
  • 20 mg three times a day for 3 days
Thereafter additional increases may be necessary, but the total daily dose should usually not exceed a maximum of 80 mg, although in hospitalized patients daily doses of 100-120 mg may occasionally be necessary. Children: Treatment should be started at a very low dose e.g. 0.3 mg/kg per day in divided doses. The dosage should be raised cautiously at 1-2 week intervals until it is sufficient for the child's individual needs. The usual dosage range for maintenance therapy is 0.75 to 2 mg/kg body weight per day. In children aged over 10 years a maximum daily dose of 2.5mg/kg bodyweight may be given.

Interaction

  • Increased sedation may occur if Baclofen is taken with agents acting on the central nervous system, alcohol or synthetic opiates. The risk of respiratory depression is also increased.
  • Combined treatment with Baclofen and antihypertensives is likely to increase the fall in blood pressure; therefore the dosage of antihypertensive medication should be adjusted accordingly.
  • The concomitant administration of Baclofen and tricyclic antidepressants may potentiate the pharmacological effects of Baclofen resulting in pronounced muscular hypotonia.
  • In patients with Parkinsons disease receiving treatment with Baclofen and levodopa and carbidopa, there have been several reports of mental confusion, hallucinations, headaches, nausea and agitation.
  • The concurrent use of MAO inhibitors and Baclofen may result in increased CNS depressant effects. Caution is advised and the dosage of one or both agents should be adjusted accordingly.
  • Caution should be exercised when administering Baclofen and magnesium sulphate or other neuromuscular blocking agents since a synergistic effect may theoretically occur.

Contraindications

Baclofen is contraindicated in patients with hypersensitivity to any component of this product.

Side Effects

The most common adverse reactions associated with Baclofen are transient drowsiness, daytime sedation, dizziness, weakness and fatigue.
  • Central Nervous System: Headache (<10%), insomnia (<10%), and rarely, euphoria, excitement, depression, confusion, hallucinations, paraesthesia, nightmares, muscle pain, tinnitus, slurred speech, co-ordination disorder, tremor, rigidity, dystonia, ataxia, blurred vision, nystagmus, strabismus, miosis, mydriasis, diplopia, dysarthria, epileptic seizures, respiratory depression.
  • Cardiovascular: Hypotension (<10%), rare instances of dyspnoea, palpitation, chest pain, syncope.
  • Gastrointestinal: Nausea (approximately 10%), constipation (<10%) and rarely, dry mouth, anorexia, taste disorder, abdominal pain, vomiting, diarrhoea and positive test for occult blood in stool.
  • Genitourinary: Urinary frequency (<10%) and rarely, enuresis, urinary retention, dysuria, impotence, inability to ejaculate, nocturia, haematuria.
  • Other: Instances of rash, pruritus, ankle oedema, excessive perspiration, weight gain, nasal congestion, visual disturbances, hepatic function disorders and paradoxical increase in spasticity. Muscular hypotonia of a degree sufficient to make walking or movement difficult may occur but is usually relieved by readjusting the dosage. For this purpose, the daytime dosage may be reduced and the evening dosage increased.

Pregnancy & Lactation

Pregnancy category B3. Safe use of Baclofen during pregnancy has not been established. Baclofen crosses the placental barrier. Baclofen should only be administered to pregnant women when in the judgement of the physician concludes that the potential benefits outweigh the possible hazards. Baclofen is excreted in breast milk however evidence to date suggests that the quantities are so small that no undesirable effects on the infant would be expected.

Precautions & Warnings

  • Lower doses (approximately 5 mg per day) should be used for patients with impaired renal function or those undergoing chronic haemodialysis.
  • Patients suffering not only from spasticity but also from psychotic disorders, schizophrenia, depressive or manic disorders or confusional states should be treated cautiously and closely monitored as exacerbations of these disorders may occur.
  • In patients with epilepsy and muscle spasticity, Baclofen may be used under appropriate supervision and provided that adequate anticonvulsive therapy is continued. Lowering of the convulsion threshold may occur and seizures have been reported after the cessation of Baclofen therapy or with overdose.
  • Baclofen should be used with caution in patients with or with a history of peptic ulcers, cerebrovascular diseases, or hepatic, renal or respiratory failure.
  • Careful monitoring of respiratory and cardiovascular function is essential especially in patients with cardiopulmonary disease and respiratory muscle weakness.
  • During treatment with Baclofen, neurogenic disturbances affecting emptying of the bladder may improve. However in patients with preexisting sphincter hypertonia, acute retention of urine may occur. Baclofen should be used with caution in these circumstances.
  • Baclofen has not significantly benefited patients with stroke. These patients have also shown poor tolerance to the medicine.
  • Appropriate laboratory tests should be performed periodically in patients with hepatic diseases or diabetes mellitus to ensure that no medicine induced changes in these underlying diseases have occurred.

Overdose Effects

Symptoms of a Baclofen overdose include vomiting, weakness, drowsiness, slow breathing,seizures, unusual pupil size, and coma.

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Brand Bazaar || Pharmacy Online Store in Bangladesh

অর্ডার করতে সরাসরি কল করুনঃ ☎ 01619550030 / 01799922318, অথবা আমাদের শো-রুমে চলে আসুন । ✅ 2০ টাকা, আপনাকে অগ্রিম প্রদান করে, অর্ডারটি কনফার্ম করতে হবে। অবশিষ্ট মূল্য কুরিয়ার অফিস থেকে পণ্য নেওয়ার সময়, কুরিয়ার আফিসে পেমেন্ট করতে হবে।

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Purchase & Delivery Process:

1.       Home Delivery inside Dhaka 50 TK, Outside of Dhaka Delivery Charge 150 TK. 2. After confirmation of the order, products will be delivered within 24 hours – 2 Days inside Dhaka and 48 hours – 5 days outside of Dhaka. 3. Outside of Dhaka, Customer have to pay 150Taka in advance 4. Outside of Dhaka delivery via courier service. 5. Product delivery duration may vary due to product availability in stock

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What is the Beklo 10mg Tablet price in bd 2024?

The Model Prescription Medicine price in BD is 10৳. In today's market on 28-03-2024. Brand Bazaar offers you the lowest price of Model Prescription Medicine: 10৳ instead of 11৳ regular price. The Model Prescription Medicine is In Stock now in our store (Call us to know about details of this product). 6 customer buy this product From 1201 visitors. Follow us on Facebook to stay updated with the latest offers. Subscribe our YouTube channel for product reviews. You can Order Model online, pay with online payment gateway or Cash on delivery (in Dhaka city) and get 2-3 day Express delivery anywhere in Bangladesh or visit our Showroom for more gift.