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Esloric 100mg Tablet

Esloric 100mg Tablet
-33 %
Product price6৳
Special price4৳
Stock Status
In Stock
Product code
8133
Brand

Product model Model
Total Reviews
Official Products 100% Official Products
Authorized Showroom Brand Bazaar
Esloric 100mg Tablet
4৳
6৳
Ex Tax: 4৳

Esloric 100mg Tablet-

Price in Bangladesh

Esloric 100mg Tablet

Indications

Allopurinol is indicated for reducing urate/uric acid formation in conditions where urate/uric acid deposition has already occurred (e.g. gouty arthritis, skin tophi, nephrolithiasis). Allopurinol is indicated for management of 2,8-dihydroxyadenine (2,8-DHA) renal stones related to deficient activity of adenine phospho ribosyltransferase. Allopurinol is indicated for the management of recurrent mixed calcium oxalate renal stones in the presence of hyperuricosuria, when fluid, dietary and similar measures have failed.

Therapeutic Class

Drugs used in Gout

Pharmacology

Allopurinol is a xanthine oxidase inhibitor which is administered orally. It acts on purine catabolism without disrupting the biosynthesis of purines. It reduces the production of uric acid by inhibiting the biochemical reactions immediately preceding its formation. Allopurinol is a structural analogue of the natural purine base, hypoxanthine. It is an inhibitor of xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine to xanthine and xanthine to uric acid, the end product of purine metabolism. Allopurinol is approximately 90% absorbed from the GI tract. Peak plasma levels generally occur at 1.5 hours to 4.5 hours. It has a plasma half life of about 1 to 2 hours. Approximately 20% of the ingested Allopurinol is excreted in the faeces.

Dosage & Administration

Adults: Allopurinol should be introduced at low dosage e.g. 100mg/day to reduce the risk of adverse reactions and increased only if the serum urate response is unsatisfactory. Extra caution should be exercised if renal function is poor. The following dosage schedules are suggested: 100 to 200 mg daily in mild conditions, 300 to 600 mg daily in moderately severe conditions, 700 to 900 mg daily in severe conditions. Children: Children under 15 years: 10 to 20 mg/kg body weight/day up to a maximum of 400 mg daily. Use in children is rarely indicated, except in malignant conditions (especially leukaemia) and certain enzyme disorders such as Lesch-Nyhan syndrome. Elderly: In the absence of specific data, the lowest dosage which produces satisfactory urate reduction should be used. Dosage in renal impairment: In severe renal insufficiency, it may be advisable to use less than 100 mg per day or to use single doses of 100mg at longer intervals than one day.

Interaction

When 6-mercaptopurine or azathioprine is given concurrently with Allopurinol, only one-quarter of the usual dose of 6- mercaptopurine or azathioprine should be given because inhibition of xanthine oxidase will prolong their activity. Evidence suggests that the plasma half-life of vidarabine is increased in the presence of allopurinol. When the two products are used concomitantly extra vigilance is necessary, to recognise enhanced toxic effects. Theophylline levels should be monitored in patients starting or increasing allopurinol therapy. An increase in frequency of skin rash has been reported among patients receiving ampicillin or amoxicillin concurrently with allopurinol compared to patients who are not receiving both drugs. Reports suggest that the plasma concentration of ciclosporin may be increased during concomitant treatment with allopurinol.

Contraindications

Allopurinol tablet is contra-indicated in patients with known hypersensitive to allopurinol.

Side Effects

Rashes, gastro intestinal disorder’s, rearly malaise, headache, vertigo, drowsiness, visual and test disturbances, hypertension, alopecia, hepatotoxicity, neuropathy, gynaeconastia and blood disorders.

Pregnancy & Lactation

There is inadequate evidence of safety of Allopurinol in human pregnancy. Use in pregnancy only when there is no safer alternative and when the disease itself carries risk for the mother or unborn child. There are no data concerning the effects of allopurinol or its metabolites on the breast-feed baby.

Precautions & Warnings

Allopurinol should be withdrawn immediately when a skin rash or other evidence of sensitivity occurs. Reduced doses should be used in patients with hepatic or renal impairment. Patients under treatment for hypertension or cardiac insufficiency may have some concomitant impairment of renal function and allopurinol should be used with care in this group.

Overdose Effects

Ingestion of up to 22.5 g allopurinol without adverse effect has been reported. Symptoms and signs including nausea, vomiting, diarrhoea and dizziness have been reported in a patient who ingested 20 gm allopurinol. Adequate hydration to maintain optimum diuresis facilitates excretion of allopurinol and its metabolites. If considered necessary haemodialysis may be used.

Storage Conditions

Store in a cool and dry place, protected from light.

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Purchase & Delivery Process:

1.       Home Delivery inside Dhaka 50 TK, Outside of Dhaka Delivery Charge 150 TK. 2. After confirmation of the order, products will be delivered within 24 hours – 2 Days inside Dhaka and 48 hours – 5 days outside of Dhaka. 3. Outside of Dhaka, Customer have to pay 150Taka in advance 4. Outside of Dhaka delivery via courier service. 5. Product delivery duration may vary due to product availability in stock

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What is the Esloric 100mg Tablet price in bd 2024?

The Model Prescription Medicine price in BD is 4৳. In today's market on 28-03-2024. Brand Bazaar offers you the lowest price of Model Prescription Medicine: 4৳ instead of 6৳ regular price. The Model Prescription Medicine is In Stock now in our store (Call us to know about details of this product). 6 customer buy this product From 1279 visitors. Follow us on Facebook to stay updated with the latest offers. Subscribe our YouTube channel for product reviews. You can Order Model online, pay with online payment gateway or Cash on delivery (in Dhaka city) and get 2-3 day Express delivery anywhere in Bangladesh or visit our Showroom for more gift.