-13 %
Product price | 23৳ |
Special price | 20৳ |
Stock Status |
In Stock |
Product code | 8057 |
Brand |
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Product model | Model |
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Xamic-500 mg-Capsule
20৳
23৳
Ex Tax: 20৳
Xamic-500 mg-Capsule-
Price in Bangladesh
Indications
Haemorrhage or risk of haemorrhage in increased fibrinolysis or fibrinogenolysis that may occur in conditions: Prostatectomy and bladder surgery, Menorrhagia, Epistaxis, Conisation of the cervix, Management of dental extraction in patients with coagulopathies, Ulcerative colitis, Haematuria, Gastrointestinal haemorrhage.
General fibrinolysis as in prostatic and pancreatic cancer, after thoracic and other major surgery, in obstetrical complications such as abruptio placentae and post- partum haemorrhage, in leukaemia and liver diseases and in connection with thrombolytic therapy with streptokinase.
Hereditary angioneurotic oedema.
Therapeutic Class
Anti-fibrinolytic drugs, Haemostatic drugs
Pharmacology
Tranexamic acid competitively inhibits activation of plasminogen (via binding to the kringle domain), thereby reducing conversion of plasminogen to plasmin (fibrinolysin), an enzyme that degrades fibrin clots, fibrinogen, and other plasma proteins, including the procoagulant factors V and VIII. Tranexamic acid also directly inhibits plasmin activity, but higher doses are required than are needed to reduce plasmin formation.
Tranexamic acid is rapidly absorbed from the gastrointestinal tract. Maximum serum levels are reached within 2-3 hours. After oral administration, about 40% of the dose is excreted in the urine during the first 24 hours. After intravenous administration 45% of the dose is excreted in the urine during the first day.
Dosage & Administration
Intravenous administration is necessary only if it is difficult to give adequate doses by mouth. The recommended standard dose is 1 to 1.5 gm or 5-10 ml by slow intravenous injection at a rate of 1 ml/minute, two to three times daily. For the indications listed below the following doses are recommended.
- Prostatectomy: 5-10 ml by slow intravenous injection every eight hours (the first injection being given during the operation) for the first three days after surgery; thereafter 1-1.5 gm orally three to four times daily until macroscopic haematuria is no longer present.
- Menorrhagia: 1-1.5 gm orally three to four times daily for three to four days.
- Epistaxis: 1.5 gm orally three times daily for four to ten days. Tranexamic Acid injection may be applied topically to the nasal mucosa of patients suffering from epistaxis. This can be done by soaking a gauze strip in the solution, and then packing the nasal cavity.
- Haematuria: 1-1.5 gm orally 2-3 times daily until macroscopic haematuria is no longer present.
- Conisation of the cervix: 1.5 gm orally 3 times a day for 12 to 14 days post-operatively.
- Dental surgery in patients with coagulopathies: Immediately before surgery, 10 mg per kg body-weight should be given intravenously. After surgery, 25 mg per kg body-weight are given orally three to four times daily for six to eight days. Coagulation factor concentrate might be necessary to administrate.
- General fibrinolysis: 1 gm by slow intravenous injection three to four times daily. With fibrinolysis in conjunction with diagnosed, increased intravascular coagulation i.e. defibrillation syndrome, an anticoagulant such as heparin may be given with caution.
- Hereditary angioneurotic oedema: 1-1.5 gm orally two to three times daily as intermittent or continuous treatment depending on whether the patient has prodromal symptoms or not.
Interaction
Clinically important interactions have not been observed with Tranexamic acid. Because of the absence of interaction studies, simultaneous treatment with anticoagulants must take place under the strict supervision of a physician experienced in this field.
Contraindications
Active thromboembolic disease, such as deep vein thrombosis, pulmonary embolism and cerebral thrombosis, Subarachnoid haemorrhage, Hypersensitivity to Tranexamic acid or any of the ingredients.
Side Effects
Dose-dependent, gastrointestinal discomfort is the most commonly reported undesirable effect, but it is usually of mild and temporary in nature. Allergic skin reactions have been reported as an uncommon undesirable effect. Hypotension may occur after fast injection.
Pregnancy & Lactation
Tranexamic acid crosses the placenta. Clinical experience of use in pregnant women is limited. Animal studies have not supplied any evidence of an increased incidence of fetal damage. Tranexamic acid is excreted into breast milk, but it is not likely to influence the child at therapeutic doses.
Precautions & Warnings
- Patients with irregular menstrual bleeding, patients with a high risk of thrombosis (a previous thromboembolic event and a family history of thromboembolic disease) should use it only if there is a strong medical indication and under strict medical supervision.
- Patients with disseminated intravascular coagulation (DIC), who require treatment with it must be under the strict supervision of a physician experienced in treating this disorder.
- In the long-term treatment of patients, regular eye examination should be performed. If a colour vision disorder should occur during the course of treatment, the drug should be discontinued.
- Tranexamic acid injection should not be mixed with blood for transfusion or infusion solutions containing penicillin.
Use in Special Populations
Children: Oral dose: 25 mg/kg 2 to 3 times daily for 7 to 10 days. Injection: 10 mg/kg 6 to 8 hours for 7 to 10 days.
Pediatric Use: The drug has had limited use in pediatric patients, principally in connection with tooth extraction. The limited data suggest that dosing instructions for adults can be used for pediatric patients needing Tranexamic acid therapy.
Storage Conditions
Store at a cool and dry place, protected from light and moisture.
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Purchase & Delivery Process:
1. Home Delivery inside Dhaka 50 TK, Outside of Dhaka Delivery Charge 150 TK. 2. After confirmation of the order, products will be delivered within 24 hours – 2 Days inside Dhaka and 48 hours – 5 days outside of Dhaka. 3. Outside of Dhaka, Customer have to pay 150Taka in advance 4. Outside of Dhaka delivery via courier service. 5. Product delivery duration may vary due to product availability in stock
What is the Xamic-500 mg-Capsule price in bd 2024?
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